Labské pískovce was originally an almost entirely forested area and the fauna present reflects this. Human activity led to the creation of new biotopes which have enriched the original forest species with types which are bound to fields, meadows and human settlements. The present day landscape offers animals a complete range of habitats from natural to those heavily influenced by human activity. In the area we can find extensive forest growths, a variety of agricultural landscapes and water courses only a little influenced, or untouched by human activity. As a result of man’s negative influences many species became extinct here, including bear, wolf, black grouse and wildcat. The lynx (Lynx lynx) is a rare visitor to the PLA. The Labe river has the greatest species diversity of fish with more than 40 species present. Typical fish for the territory are barbel (Barbus barbus), vimba bream (Vimba vimba), zander (Stizostedion lucioperca) or eels (Anguilla anguilla). A reintroduction programme to return the Atlantic salmon(Salmo salar) to Bohemia and Saxony has been in operation since 1999, including the Kamenice river. We can also find brook lamprey (Lampetra planeri) in the catchments of the Křinice and Kamenice rivers.
Among 16 recorded species of amphibians we can commonly meet the common toad (Bufo bufo), marsh frog (Rana ridibunda), fire salamander (Salamandra salamandra), great-crested newt (Triturus cristatus) and Alpine newt (Triturus alpestris). If we are lucky, we might see agile frogs (Rana dalmatina) or moor frog (Rana arvalis).
Eight species of reptiles have been recorded in the region. Unfortunately European pond terrapins (Emys orbicularis) became extinct more than 100 years ago, and there are no sightings of dice snake (Natrix tesselata) in recent decades. The smooth snake (Coronella austriaca) is becoming more common. Throughout the whole PLA territory we can find common viper (Vipera berus), viviparous lizard (Zootoca vivipara) and slowworm (Anguis fragilis).
More than 100 species of birds nest in the area. Black storks (Ciconia nigra) regularly bring up their young in the area’s forests. Since the mid – 1990s, the peregrine falcon (Falco peregrinus) has returned to the area. 7 species of owls have been confirmed as nesting in the area. In recent years the nightjar (Caprimulgus europaeus) has been sighted on burnt ground. Kingfisher (Alcedo athis) and dipper (Cinclus Cinclus) are common on the rivers. More than 50 species of mammals live in the area. On the Labe river we can again encounter European beaver (Castor fiber) and otters (Lutra lutra) can be found on all suitable water courses. The fat dormouse (Glis glis) is commonly sighted. 16 species of bat have been identified, including lesser horseshoe bat (Rhinolophus hipposideros), greater mouse-eared bat (Myotis myotis) and parti-coloured bat (Vespertilio murinus).
From the great variety of invertebrates living in Labské pískovce we can mention the freshwater mussel Unio pictorum, the cave cricket - Pholidoptera aptera, the swallowtail butterfly (Papilio machaon), the ground beetles Carabus nitens, Carabus irregularis and Carabus problematicus, European rhinoceros beetle (Oryctes nasicornis) as well as more common invertebrates such as the broad-bodied chaser dragonfly (Libelula depressa).